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COMPLEMENT C3
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DeCS
Descriptor
English
:
Complement C3
Descriptor
Spanish
:
Complemento C3
Descriptor
Portuguese
:
Complemento C3
Tree Number:
D12.776.124.050.140
D12.776.124.486.274.250
Definition
English
:
A glycoprotein that is central in both the classical and the alternative pathway of
COMPLEMENT ACTIVATION
. C3 can be cleaved into
COMPLEMENT C3A
and
COMPLEMENT C3B
, spontaneously at low level or by
C3 CONVERTASE
at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with
C3 convertase
to form C5 convertase.
Pharmacological Action:
Immunologic Factors
History Note
English
:
2006 (1975)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22135
Unique Identifier:
D003176
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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